commercial finite element analysis software comsol multiphysics  (COMSOL Inc)

Journal: Frontiers in thermal engineering

Article Title: Design of a temperature-feedback controlled automated magnetic hyperthermia therapy device

doi: 10.3389/fther.2023.1131262

Figure Lengend Snippet: (A) Experimental validation of simulated open loop temperature change vs. time responses in the agarose gel + Cu wire system, to a 30 s AMF pulse. The responses were tested to 30 s AMF pulses of amplitude 4.2 kA/m and 9.8 kA/m peak field (160 kHz), respectively, which define the limits of the AMF field range used in PID control (4.2–9.8 kA/m peak, 160 kHz). Solid lines indicate experimentally measured temperature vs. time curves during heating (AMF ON) and cooling (AMF OFF) at 53 Oe (4.2 kA/m, lower curve) and 123 Oe (9.8 kA/m, upper curve). Dashed lines are obtained from the finite element analysis (FEA) agarose gel + Cu wire model, with the lower dashed curve corresponding to AMF amplitude of 53 Oe (4.2 kA/m) and upper dashed curve corresponding to AMF amplitude of 123 Oe (9.8 kA/m). (B,C) Estimation of heating time constants, from open loop temperature vs. time responses of the agarose gel + Cu wire system, for evaluation of PID gains for feedback control. (D) Closed loop temperature vs. time response of gel + Cu wire system with proportional gain, used to evaluate the undamped natural frequency of the system, ω n ~ 0.2 rad / s .

Article Snippet: The agarose gel + Cu wire system was modeled using commercial finite element analysis (FEA) software COMSOL Multiphysics (COMSOL Inc., Burlington, MA) to characterize the open loop temperature vs. time response to a step increase in magnetic field amplitude.

Techniques: Biomarker Discovery, Agarose Gel Electrophoresis, Control